MCQ in Biopharmaceutics and pharmacokinetics BP604 T (Bioavailability and Bioequivalence) Quiz – 2

 

MCQ in Biopharmaceutics & Pharmacokinetics 

BP604 T (Bioavailability and Bioequivalence) 

Quiz – 2

MULTIPLE CHOICE QUESTIONS

Third Yr. B.PHARM  SEM-VI

AS PER PCI SYLLABUS

1. What is pharmaceutic equivalence?

  A) Two or more drug products contain the same labeled chemical substance giving a different therapeutic effect 
B) Two or more drug products contain the same labeled chemical substance in the same amount
C) Two or more drug products are identical in quality, purity, uniformity, disintegration, dissolution
D) Two or more drug products contain different labeled chemical substance giving the same therapeutic effect

... Answer is : C) Two or more drug products are identical in quality, purity, uniformity, disintegration, dissolution

2. What is bioequivalence?

A) Two or more drug products contain the same labeled chemical substance giving a different therapeutic effect
B) Drug substance reaches the systemic circulation at the same rate in two or more identical dosage
C) Two or more drug products contain the same labeled chemical substance in different quantity
D) Two or more drug products contain different labeled chemical substance giving the same therapeutic effect

... Answer is : B) Drug substance reaches the systemic circulation at the same rate in two or more identical dosage

3. What is therapeutic equivalence?

A) Two or more drug products contain the same labeled chemical substance giving a different therapeutic effect
B) Two or more drug products contain the same labeled chemical substance in the same amount
C) Two or more drug products contain the same labeled chemical substance in different quantity
D) Two or more drug products contain the same labeled chemical substance giving the same therapeutic effect

... Answer is : D) Two or more drug products contain the same labeled chemical substance giving the same therapeutic effect

4. On which individuals study of newly invented medicines are not done?

A) Adult male
B) Fasting person
C) Healthy person
D) Pregnant and elderly

... Answer is : D) Pregnant and elderly

5. What should be the disadvantage of cross over study on volunteers?

A) Minimize the carry-over effect
B) Minimizes variations due to time effect
C) Takes a lot of time to get the result of the study
D) Minimize the intersubject variability in plasma drug levels

... Answer is : C) Takes a lot of time to get the result of the study

6. Which of the following is not an approach for overcoming bioavailability problems? .

A) Partition coefficient approach
B) Pharmaceutic approach
C) Pharmacokinetic approach
D) Biologic approach

... Answer is : A) Partition coefficient approach

7. What will be the particle size after micronization of drugs?

A) 1-5 micron
B) 1-10 micron
C) 10-20 micron
D) 20-30 micron

... Answer is : B) 1-10 micron

8. What is the principle behind the use of surfactants?

A) Improving solubility
B) Alter the pH of the microenvironment
C) Reducing the size of solid drug particles
D) Enhancing the dissolution rate by promoting wetting

... Answer is : D) Enhancing the dissolution rate by promoting wetting

9. How pH alteration of the drug microenvironment is done?

A) In situ salt formation
B) Altering the pH of the tissue
C) Altering the pH while the administration
D) Formulating the drug in such a way that it gets activated only when it reaches the tissue pH

... Answer is : A) In situ salt formation

10. Which one of the following is used for selective adsorption on insoluble carriers of the drugs?

A) Creating metastable polymorphs
B) Inorganic clays like bentonite
C) Freeze drying
D) Organic solvent

... Answer is : B) Inorganic clays like bentonite