MCQ in Biopharmaceutics and pharmacokinetics BP604 T (Distribution) Quiz – 1

 

MCQ in Biopharmaceutics and pharmacokinetics 

BP604 T (Distribution) Quiz – 1

MULTIPLE CHOICE QUESTIONS

Third Yr. B.PHARM  SEM-VI

AS PER PCI SYLLABUS

1. Which one of the following sentences will be the actual definition of distribution?

  A) Reversible transfer of drug between blood and extravascular fluids and tissues 
B) Transfer of drug from the administration dosage to surrounding fluid
C) Transfer of drug from the surrounding the fluid to the blood
D) Transfer of the drug from the oral cavity to the intestine

... Answer is : A) Reversible transfer of drug between blood and extravascular fluids and tissues

2. What should be the molecular weight of the drug molecules so that they can easily pass through the membrane?

A) 500-600 Dalton
B) 200-400 Dalton
C) 600-800 Dalton
D) 300-500 Dalton

... Answer is : A) 500-600 Dalton

3. Which type of drug cannot enter the cell membrane in the below picture?

A) Unhydrated drug
B) Hydrolyzed drug
C) Ionized drug
D) Unionized drug

... Answer is : C) Ionized drug

4. Which drugs cannot pass the Capillary endothelial Barrier?

A) Drugs bound to a chemical moiety
B) Molecular size less than 600 Dalton
C) Drugs bound to blood components
D) All drugs can pas

... Answer is : C) Drugs bound to blood components

5. Which of the following drug cannot pass through the plasma membrane barrier?

A) Drug size less than 50 Dalton
B) Lipophilic drugs 50-600 Dalton
C) Polar or ionized drugs of size greater than 50 Dalton
D) Drug size more than 600 Dalton

... Answer is : D) Drug size more than 600 Dalton

6. What is the name of the specialized cells that support the blood-brain barrier tissue?.

A) Fat cells
B) Dendrites
C) Astrocytes
D) Endothelial cells

... Answer is : C) Astrocytes

7. Why dopamine cannot be administered for the disease Parkinsonism?

A) Forms aggregate and thus cannot cross the BBB
B) Cannot cross the blood-brain barrier
C) Don’t have a medicine
D) It is not the medicine

... Answer is : B) Cannot cross the blood-brain barrier

8. Which one of these is not an approach to make the drug cross the blood-brain barrier?

A) Using permeation enhancers
B) Use of highly lipophilic drug only
C) Use of drug carriers to cross the BBB
D) Osmotic disruption of the blood-brain barrier

... Answer is : B) Use of highly lipophilic drug only

9. Which drugs can easily pass the Placental barrier?

A) Analgesics, antibiotics, etc
B) Moderate to high lipid solubility
C) Drugs having a molecular weight less than 1000 Dalton
D) Drugs having a molecular weight less than 1000 Dalton and moderate to high lipid solubility, analgesics, and antibiotics

... Answer is : D) Drugs having a molecular weight less than 1000 Dalton and moderate to high lipid solubility, analgesics, and antibiotics

10. What is the function of the blood-testis barrier?

A) Restricts the passage of drugs to spermatocytes and spermatids
B) Restricts the passage of drugs to spermatocytes
C) Restricts the passage of drug to the testis
D) Restricts the passage of drug to sperms

... Answer is : A) Restricts the passage of drugs to spermatocytes and spermatids