MCQ Pharmaceutical Chemistry 


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                            Multiple choice question with answer                 

                                                                            

1.True regarding acetazolamide

a. Irreversible inhibitor of carbonic anhydrase

b. structural resemblance to sulfonamides

c. It decreases Na, K and glucose execration

d. it causes metabolic alkalosis

 

2.Glycerol is an

a. osmotic diuretic

b. purgative

c. antidiabetic

d. antiemetic

 

3. Drug causing gynecomastia is

a. spironolactone

b. Rifampicin

c. penicillin

d. bumetanide

 

4.which of the following is a mineralocorticoids antagonist

a. spironolactone

b. Inamrinone

c. nicorandil

d. ketorolac

 

5.Diuretics that can be used in renal failure is

a. furosemide

b. mannitol

c. chlorthalidone

6.Maximunm potassium loss is caused by which diuretics

a. furosemide

b. spironolactone

c. Thiazide

d. acetazolamide

 

7.spironolactone should not be given with

a. Chlorthiazide

b. Beta- bloker

c. ACE - Inhibitor

d. amlodipine

 

8.A drug which gets bio-transformed rapidly is known as Hard drug

a. True

b. False

c. both

 

9. Which diuretic is potassium sparing?

a. Lasix® (furosemide)

b. Aldactone® (spironolactone)

c. Diamox® (acetazolamide)

d. Hydrodiuril® (hydrochlorothiazide)

 

10.hypokalemia is one of the majors constrains of

a. High Ceiling Loop Diuretics

b. Carbonic Anhydrase Inhibitor

c. Aldosterone Antagonist

d. Osmotic Diuretic

 

11.Ethacrynic acid belongs to the class of

a. Loop diuretic

b. ACE inhibitor

c. Antiarrhythmic

d. Diuretic

 

12.Prodrugs with two active compounds are known as __________

a. Mixed type prodrugs

b. Pro-prodrugs

c. Bioprecursors

d. Mutual prodrug

 

13.Which of the following is the correct characteristic of bio precursors/ metabolic precursors?

a. The inert carrier is attached through a chemical bond

b. There is no inert carrier

c. There is a change in pH while the formulation

d. The active drug is converted to its inert form chemically

 

14.. Which of the following is not a characteristic of ideal prodrug?

a. Should rapidly transform, chemically and enzymatically forming the active product

b. Should have intrinsic pharmacological activity

c. The vapour pressure should be less and evaporate easily

d. Apart from an active product, other metabolic fragments should be nontoxic

 

15. The principle of prodrug design is known as chemical formulation.

a. True

b. False

 

16.   Which of the following will not be a limitation for prodrug design?

a. Formation of toxic product

b. An inert carrier can be cleaved off forming toxic product

c. Product cleaving off before reaching the target site

d. The cleaving of the carrier is also site-specific

 

17.Which of the following are fully synthetic opioids?

a. Codeine

b. Oxycodone

c. Fentanyl

d. Endomorphins

 

18.Which one is the antagonist for heroin?

a. Naloxone

b. Oxycodone

c. Fentanyl

d. Endomorphins

 

19.morphine has high affinity for in which opioid receptor

a. Mu (µ)

b. k(kappa)

c. delta (d)

d. all of the above

 

20. In diabetes insipidus, diuretics showing paradoxical antidiuretics activity

a. spironolactone

b. Thiazide

c. triamterene

d. Pethidine contains a quaternary nitrogen.

 

21.Levocetrazine is

a. R isomer of cetirizine

b. S isomer of cetirizine

c. E isomer of cetirizine

d. Z isomer of cetirizine

22.A high ceiling diuretic having a furan ring system is 

a. Ethacrynic acid

b. Furosemide

c. Bumetanide

d. Acetozolamide

 

23.which of the following drug is having at 1/1 1,3,4 thiadiazole ring system

a. Acetazolamide

b. Dichlorophenamide

c. Furosemide

d. Spiranolactone

 

24.which of the earliest discovered prodrug

a. prontosil

b. aspirin

c. salicylic acid

d. sulphanilamide

 

25. diuretic which can be given in mild to moderate hypertension?

a. loop diuretics

b. thiazide diuretics

c. osmotic diuretics

d. potassium sparing diuretics

 

26.ADH acts on

a. loop of henle

b. collecting duct

c. distant convoluted tubule

d. proximal convoluted tubule

 

27.The diuretics group that does not require access to tubular lumen to induce diuresis is

a. carbonic anhydrase inhibitor

b. Na-Cl symport inhibitor

c. mineralocorticoid antagonist

d. Na- K symport inhibitor

 

28.H1 histamine receptors location.

a) bone marrow

b) parietal cells

c) Thymus

d) smooth muscles

 

29.thizide causes

a. metabolic alkalosis

b. metabolic acidosis

c. respiratory alkalosis

d. respiratory acidosis

 

 

30.mannitol is not used in

a. acute renal failure

b. pulmonary edema

c. cerebral edema

d. all of the above


1. b

2. a

3. a

4. a

5. a

6. d

7. c

8. b

9.b

10. a

11.a

12. b

13. d

14. c

15. a

16. d

17. c

18. a

19.a

20. b

21. a

22. b

23. a

24. a

25. b

26. b

27.c

28.d

29. a

30. d