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Answer KEY Given end of question
1) Which ocular DDS has the largest particle size among these?
A. Liposome
B.
Niosome
C. Discosome
D. Liposome and Niosome
2) Water content in Eyes
A. 95%
B. 98%
C. 96%
D. 97%
3) Which factor not affects ocular
absorption?
A. GI pH
B. Lacrimal drainage
C. Dilution of dose
D.
Protein in lacrimal fluid
4) Which ocular DDS from following have
maximum contact time
A. Ointment
B. Oily eye drop
C. Ocular road
D. Eye lotion
A. Sterility
B. Isotonicity
C. Less drainage tendency
D.
Maximum protein binding
6) Matting of eyelid is side effect of
A. Eye ointment
B. Eye
gel
C. Both eye ointment and eye gel
D. Ocusert
7) Which is not a erodible type of ocular DDS
among these
A. Lacrisert
B. Ocusert
C. SODI
D. Minidisc
8) Which is not the property of TDDS
A. Non invasive
B. Sustained effect
C. GI irritation
D. Self-administration
9) Which is not a limitation of TDDS?
A. High molecular weight
B. High dose of drug
C. Low molecular weight
D. All
of these
10) Which GRDDS technique required external
assistance?
A. Floating approach
B. Muco-adhesive approach
C. Magnetic approach
D. Sinking approach
11) Zinc oxide and titanium oxide used in
which GRDDS approach?
A. Low densitysystems
B. High densitysystems
C. Magnetic systems
D. Swelling systems
12) In which portion of the stomach, food
stored?
A. Pyloric
B. Body
C. Cardia
D. Lesser curvature
13) For high-density system, the density
should be in the range
A. 1-2 gm/ml
B. 1.5-2.1 gm/ml
C. 1.7-2.3 gm/ml
D. 09-1.7 gm/ml
14) Which is an ideal condition for GRDDS
A. Low fluid in stomach
B.
Retention of GRDDS in antrum part
C. Achlorhydria
D. Drug having narrow therapeutic index
15) Which is not the advantage of colon
specific drug delivery system (CSDDS)?
A. Higher absorption of protein and peptide
drugs
B. Lower drug degradation
C. Site specific delivery
D. Higher absorption of drug from small
intestine
16) Inflammatory bowel disease related to
A. Stomach
B. Colon
C. Rectum
D. Pylorus
17) Which dosage form is not related to colon
specific drug delivery system (CSDDS)?
A. DOTS
B. OROS-CT
C. PULSINCAP
D.
CODES
18) Which is not the disadvantage of colon
specific drug delivery system (CSDDS)?
A. Drug degradation of microbial flora
B. Small luminal surface area
C. Slow onset of action
D. Prolonged drug release
19) Keratinized oral epithelial layer
A. Increase bioavailability
B. Decrease bioavailability
C. No effect on bioavailability
D. Enhance solubility
20) Which is the right sequence of the
mechanism of bio adhesion in mucosal DDS?
A. swelling>wetting>inter
penetration> entanglement>chemical bond
B. wetting>swelling>inter
penetration> entanglement>chemical bond
D.
wetting>swelling>entanglement>inter penetration>chemical bond
21) Which API is suitable for mucosal DDS?
A. With high biological half life
B. Mol. Wt. more than 1000 D
C. Irritant to buccal mucosa
D.
Drug degraded in GI tract
22) “Arion lustanicus” is used in which the
evaluation test of mucosal DDS
A. Hygroscopicity test
B. Folding endurance test
C. Slug irritation assay
D. In-vitro residence time
23) The absorption of the ophthalmic drug
does not depend on which of the following?
A. Physicochemical properties of the
permeating molecule
B. Drainage of tears
C. Output of tears
D. Size of the eyeball
24) Which of the following should not be a
property of implants?
A. Environmental stable
B. Biostable
C. Non-toxic
D. Non removable
25) Which of the following is a
characteristic of nanoparticles?
A. Free flowing powder
B. Size range 10-100 nm
C. Control drug release by partitioning the
drug from the oil
D. Aqueous solutions
26) Which of the following is a
characteristic of resealed erythrocytes?
A. Nonimmunogenic
B. Aqueous solutions
C. Control drug release by partitioning the
drug from the oil
D. Size range 10-100 nm
27) Which of the following statement is false
for osmotic pumps?
A. The pump has three concentric circle
B. The innermost is the drug reservoir
C. The drug is contained a permeable
polyester bag
D. Outer most rigid rate controlling
semipermeable membrane
28) What is the characteristic of altered
density systems?
A. The dosage form either sink or float in
stomach
B. The dosage form dissolve rapidly
C. The dosage form is liquid in nature
D. Drug release is observed in small
intestine only
29) What is the characteristic of
mucoadhesive systems in GRDDS?
A. The dosage form is liquid in nature
B. Free flowing powders
C. Usage of bio adhesive polymer
D. Use of high or low density pellets
30) Enteric coating is used for which
systems?
A. Mucoadhesive systems
B. Size based systems
C. Intestinal release systems
D. Buccal drug delivery systems
31) What is the characteristic of colonic
release systems?
A. Release the drug along the entire length of GIT
B. Prolonged their residence in the GIT and release
C. Usage of polymers that dissolves only in the alkaline pH of colon
D. Use
of enteric coating
32) The disadvantage for implantsis-
A. More effective
B. More prolonged action
C. Significantly small dose
D. Need of microsurgery
33) Name two different types of inhaler?
A. MDI and API
B. IV and SC
C. DPI and MDI
D. GIT and AT
34) What are the characteristics of the
reservoir or membrane devices?
A. The drug has a large therapeutic index
B. Drug permeation rate is high
C. Control drug release by partitioning the
drug from the oil
D. Administration of emulsions
35) Factors to be considered in designing of
colon specific drug delivery is
A. Diameter of lumen of colon
B. Refractive index of drug
C. Available dosage form
D. Colonic microflora
36) Name the approach of colon specific drug
delivery in which hydrolysis of sulfasalazine in to 5-aminosalicylic acid and
sulphapyridine is carried out
A. Coating with azo polymers
B. Prodrug
C. Hydrogels
D. Polysacharides as carriers
37) Full form of SODI is
A. Soluble ocular direct injection
B. Soluble ocular drug insert
C. Soluble diffusion implants
D. Soluble dissolution implants
38) Which statement is correct about
Gastroretentive drug delivery system?
A. Drug should show absorption in stomach
only
B. Dose of the drug should be aslow as
possible
C. Drug should be water soluble
D. Drug should be water insoluble
39) Polymer membrane permeation- controlled
drug delivery occurs by
A. Non porous membrane
B. Micro porous membrane
C. Semi permeable membrane
D. All of the above
40) Alzet Pump is an example of
A. Osmotic pressure activated
B. Vapor pressure activated
C. Magnetically activated
D. Hydrolytic-activated
41) Which of the following is incorrect for
conventional drug delivery for ocular drug delivery?
A. Less Bioavailability
B.
Protein binding
C. Lacrimation
D.
Long residence time
42) Which animal is used in pharmacokinetic
evaluation of Buccal drug delivery system
A. Rat
B. Mouse
C. Guinea pigs
D.
Rabbit
43) Colon targeted drug delivery system is
used for
A. Local action
B. Systemic action
C. Topical action
D. All of the above
44) In dendrimer synthesis assembly of
molecule from core, extending radially to the periphery is known as
A. Convergent synthesis
B. Divergent synthesis
C. Double exponential
D. Chemical Synthesis
45) In dendrimer synthesis when a critical
branched state isreached which cannot further grow due to lack of space is
known as
A. Star Bust effect
B. Star Rust effect
C. Star Galaxy effect
D. None of the above
46) Ophthalmic dosage forms should be
A. Liquid
B. Solid
C. Sterile
D. Partially sterile
47) Under normal conditions the human tear
volume averages about
A. 7 microliters
B. 10
microliters
C. 25 microliters
D. 15 microliters
48) Heat-sensitive ophthalmic formulation may
be sterilized by
A. Moist heat sterilization
B. Dry heat sterilization
C. Boiling with chemicals
D. Gaseous sterilization
49) The weight of sodium chloride that will
produce the same osmotic effect as 1 g of the drug is known as
A. E value
B. B Value
C. D value
D. A value
50) Increased intraocular pressure is one of
the symptoms of
A. Conjunctivitis
B. Glaucoma
C. Diabetic Retinopathy
D. None of the above
51) The time for which the dosage form
continuously floats on the dissolution media is termed as
A. Floating Time
B.
Buoyancy lag time
C. Floating lag time
D. None of the above
52) 13C Octanoic acid Breath test is used in
evaluation of
A. GRDDS
B. Pulmonary DDS
C. Transdermal DDS
D.
Nasal DDS
53) The absorption of the ophthalmic drug
does not depend on which of the following?
A. Physicochemical properties of the
permeating molecule
B. Drainage of tears
C. Output of tears
D. Size of the eyeball
54) The anterior transparent part of the eye
is
A. Pupil
B. Conjunctiva
C. Cornea
D. Sclera
55) The nerve which is responsible for the
vision is
A. Olfactory
B. Facial
C. Optic
D. Acoustic
56) Light rays entering the eyes is
controlled by
A. Pupil
B.
Iris
C. Cornea
D. Lens
57) Fluid in the posterior chamber of the
eyes is called as
A. Vitreousfluid
B. Aqueousfluid
C. Both
D. None
58) Which is the innermost layer of eyes
A. Sclera
B.
Retina
C. Cornea
D. Iris
59) Which of the following formulations would
not be applicable to ocular administration?
A. Solution
B.
Liniment
C. Suspension
D. Ointment
60) Which one of the following medicines does
not rely on topical drug delivery?
A. Nasal spray
B. Anti-dandruff shampoo
C. Insulin pen
D. Nicotine patch
61) Which component enhance percutaneous
absorption
A. Lactose
B.
DMSO
C. Fructose
D. HPMC
62) Colon targeted drug delivery system is
used for
A. Local action
B. Systemic action
C. Topical action
D. All of the above
63) The pH in the stomach usually is between
A. 1-3
B. 3-5
C. 5-7
D. 7-9
64) The gastric emptying time at small
intestine commonly is
A. 1-2 hrs
B. 3-4 hrs
C. 7-8 hrs
D. 12-24 hrs
65) The enzymes that are mainly targeted for
colon drug delivery include
A. Azoreducatase-galactosidase
B. Î’-xylosidase
C. Nitroreductase
D. All of the above
66) Mucosa is covered by
A. Islet cells
B. Beta cells
C. Goblet cells
D. Alpha cells
67) Which of the following is not one of the
theories of muco-adhesion
A. Electronic theory
B. Wetting theory
C. Adsorption theory
D. Adhesion theory
68) Mucoadhesive drug delivery system are not
available for
A. Ocular
B. Nasal
C. Buccal
D. Topical
69) Which of the following are used as
penetration enhancers?
A. Benzalkonium chloride
B. Dextran sulfate
C. Fatty acid
D. All of the above
70) Which of the following is not a component
of mucus?
A. Protein
B. Lipid
C. Sugar
D. Salt
A. Surfactant
B.
Phospholipid
C. Cholesterol
D.
None
72) For liposome preparation, which of the
following is not a mechanical dispersion method?
A. Lipid film hydration
B. Sonication
C. French pressure cell
D. Ethanol injection
73) Factor which affect gastro retentive
system
A. Size
B. Shape
C. Density
D. All of the above
74) Choose from the following, Ideal characteristics
of TDDS
1) Toxic,
2) Non-toxic, 3)
Biocompatible, 4) Biodegradable, 5) Physicochemical stable
B.
2,3,4,5
C. 1,2,3,5
D. 1,2,3,4,5
|
1. C |
2. B |
3. A |
4.C |
5. D |
6. C |
7. B |
8. C |
|
9. C |
10. C |
11. B |
12. C |
13. B |
14. B |
15. C |
16. B |
|
17. A |
18. D |
19. B |
20. B |
21. D |
22. C |
23. D |
24. D |
|
25. B |
26. A |
27. C |
28. A |
29. C |
30. C |
31. C |
32. D |
|
33. C |
34. C |
35. D |
36. B |
37. B |
38. A |
39. D |
40. A |
|
41. A |
42. D |
43. D |
44. B |
45. A |
46. C |
47. A |
48. C |
|
49. A |
50. B |
51. B |
52.A |
53. D |
54. C |
55. C |
56. B |
|
57. B |
58. B |
59. B |
60. B |
61. B |
62. A |
63. A |
64. A |
|
65. A |
66. C |
67. D |
68. A |
69. A |
70. C |
71. B |
72. D |
|
73. D |
74. B |
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