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MULTIPLE CHOICE QUESTIONS
T-4.8.5 Pharmacology-IV
1) Identify dermatological
disorders from followings:
A. Erythema Multiforme
B. Lyell’s Syndrome
C. Hirsutism
D. All of the above
2) Limitation of TDM
is___________________.
A. Laboratory variability in reporting
B. Procedure is toxic
C. Not useful to society
D. All of the above
3) What is IND?
A. Investigational New Drug
B. Insisted New Drug
C. International New Drug
D. Inhibited New Drug
4) What term is used to signify a preparation that appears identical
to the preparation of an active drug but which has no biological activity?
A. Dummy drug
B. Peptidomimetic drug
C. Gazebo
D. Placebo
5) On what does Phase 2 clinical trials test?
A. Widespread differentiated population
B. Animals: only rats/mice
C. Healthy human volunteers
D. Large scale tests in people having target disease condition
A. Cardiac toxicity
B. Acute hemolytic states can result in ARF
C. Liver toxicity
D. Ocular toxicity
7) All of the following are known adverse effects of
thalidomide, except:
A.Diarrhoea
B.Teratogenicity
C.Deep Vein Thrombosis
D.Peripheral Neuropathy
8) What is informed consent in a clinical trial?
A. The subjects do not know which study treatment they receive
B. Patients injected with placebo and active doses
C. Fake treatment
D. Signed document of the recruited patient for the clinical trial
procedures
9) What type of medication error is forgetting to give the patient the
medication?
A. Documentation Error
B. Prescription Error
C. Dispensing Error
D. Administration Error
10) The drug whose activity is affected by drug interaction is called
as _______________.
A. Object drug
B. Precipitant drug
C. Both A and B
D. None of the above
11) On what does Phase 3 trials test?
A. Animals
B. Healthy Human volunteers
C. Randomized trial with group of patients
D. None of the above
12) Pharmacovigilance is applicable for_________________.
A. Drugs in clinical trial
B. Drugs in clinical trial and in market
C. Only for phase III trial
D. None of the above
13) The goal of TDM is to ensure the__________________.
A. Minimum therapeutic benefits
B. Maximum toxic effects
C. Maximum therapeutic benefits
D. None of the above
14) Pharmacovigilance is related with __________________.
A. Detection
B. Assessment
C. Prevention of ADR
D. All options are correct
15) Drug interactions can be managed by________________.
A. Avoiding the combinations
B. Avoiding the drugs at all
C. Avoiding the physician
D. All of the above
16) ANDA is for_____________.
A. Generic drug approval
B. Clinical trial
C. Pre-clinical trial
D. All of the above
17) A medication error is_________________.
A. May cause or lead to inappropriate medication use
B. May be preventable event
C. Option A and B is correct
D. Both A and B is incorrect
18) Otitis media is______________.
A. Infection of external ear
B. Infection of inner ear
C. Infection of middle ear
D. Infection of eye
19) What is the purpose of Investigational New Drug (IND) Application?
A. Permission to administer a new drug to humans
B. Permission to administer a new drug to animals
C. Permission to market a new drug
D. Permission to manufacture the new drug
20) Identify the correct statement about phase-II clinical trial.
A. Used for the study of drug absorption & metabolism in human
B. Used for the study of drug effectiveness in treating the disease &
short term side effects in
patients
C. Used for the study of drug safety (Benefits v/s risk analysis) &
long term side effects in
patients
D. Used for the study of drug safety and effectiveness after the
launching of drug in the market
21) Identify the aim of new drug development.
A. Develop clinically efficacious & safer drugs
B. Develop economically viable drug
C. Discover entirely new class of drugs
D. All options are correct
22) Select the number of volunteers or patients usually involved in
Phase-III clinical trial.
A. 20 to 100
B. 100 to 300
C. 1000 to 3000
D. More than 50000
23) Find the Non-beneficial drug interaction from the followings:
A. Antipsychotic drug + Antiparkinson drug
B. Antihypertensive drug + Diuretic drug
C. Bacteriostatic drug + Bactericidal drug
D. High ceiling diuretic + Potassium sparing diuretic
24) Select the mechanism of pharmacokinetic drug interaction that is
related with or influenced by the factor hypoalbuminemia.
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
25) Identify the factor which is NOT responsible for the alteration of
GIT absorption and subsequent drug
interaction.
A. Alteration of intestinal pH
B. Complexation
C. Displacement from protein binding sites
D. Alteration of GIT motility
26) The term tinnitus belongs to which type of iatrogenic condition?
A. Nephrotoxicity
B. Carcinogenicity
C. Ototoxicity
D. Teratogenicity
27) Identify the drug induced
hematologic disorder in which the clinical manifestations are usually related
with hemorrhage like ecchymosis, epistaxis & petechiae.
A. Agranulocytosis
B. Thrombocytopenia
C. Megaloblastic anemia
D. Aplastic anemia
28) Select the pharmacodynamic drug interaction (synergism) from the
followings:
A. Folic acid deficiency anemia in patients receiving phenytoin
B. Risk of hemorrhage in patients taking phenylbutazone and warfarin
C. Use of disulfiram in the treatment of alcohol addiction
D. Excessive CNS depression after the use of alcohol and sedatives
29) Drug induced agranulocytosis is which type of iatrogenic disease?
A. Haematological
B. Dermatological
C. Teratogenic
D. Carcinogenic
30) Which of the following is an iatrogenic condition?
A. Plague
B. Cancer
C. Corona virus disease
D. Leishmaniasis
31) Detect the statement that is NOT CORRECT with respect to TDM.
A. Process of ensuring drug concentration within the therapeutic range
B. Aims at optimizing the dose for large number of patients
C. Establishes safety and effectiveness of therapy
D. Process that assess concentration of drug in plasma
32) Select the condition that needs TDM.
A. Drug following linear kinetics
B. Drugs with wide therapeutic range
C. Hit and run drugs like MAO inhibitors
D. Drugs following saturation metabolism
33) In TDM, if the sample is obtained just prior to the next dose at
steady-state conditions it is referred
as _______.
A. Peak concentration
B. Trough concentration
C. Random concentration
D. Biological concentration
34) Select the appropriate source for the recommended therapeutic ranges
of drugs that need TDM.
A. Physician desk reference
B. Product inserts
C. Physician desk reference & product inserts
D. All options are incorrect
35) Which of the following is NOT the type of medication error?
A. Process based errors
B. Knowledge based errors
C. Rule based errors
D. Action based errors
36) Inaccurate medication history taking primarily leads to which type
of medication error?
A. Dispensing error
B. Administration error
C. Prescribing error
D. Compliance error
37) Tall Man lettering (mixing upper and lower case letters in the
same word) can be used to avoid
which types of errors.
A. Knowledge based errors
B. Action based errors
C. Rule based errors
D. Memory based errors
38) NDA is for?
A. Approval from FDA for sale and marketing
B. Approval from FDA for Clinical trial
C. Approval from FDA Pre-clinical trial
D. All of the above
39) Drugs such as nitrofurantoin or triamterene induces_____________.
A. Cardiac toxicity
B. Acute hemolytic states, can result in ARF
C. Liver toxicity
D. Ocular toxicity
40) The interaction between penicillin and probenecid is example
of___________.
A. Desirable drug-drug interaction
B. Undesirable drug-drug interaction
C. Timely drug interaction
D. None of the above
41) What is ANDA?
A. Abbreviated New Drug Application
B. Anything as New Drug Application
C. All New Drug Application
D. None of the Above
42) Toxic epidermal necrolysis (TEN) is a type of____________.
A. Drug induced kidney diseases
B. Drug induced skin diseases
C. Drug induced liver diseases
D. Drug induced ocular diseases
43) Whole blood can be used as a sample for a process of TDM
because____________.
A. There are large shifts of drug between red cells and plasma with
temperature change
B. It is more convenient
C. It is easy to collect
D. All of the above
44) Drugs liable for enzyme induction are prone to______________.
A. Increase metabolism
B. Decrease metabolism
C. Do nothing with metabolism
D. Increase absorption
45) What is phase-III clinical trial?
A. The subjects do not know which study treatment they receive
B. Patients injected with placebo and active doses
C. Randomized control trial with group of patients
D. Clinical trial procedures on normal individuals
A. Object drug
B. Precipitant drug
C. Both A and B
D. None of the above
47) What type of medication error is forgetting to give the patient
the medication?
A. Documentation Error
B. Prescription Error
C. Dispensing Error
D. Administration Error
48) Lead optimization in drug discovery is__________________.
A. Alter the structure of lead candidates to improve its properties
B. Change the properties of compound without structural alterations
C. Optimize the methodology
D. None of the above
49) Pharmacist has to remember while delivering a
medication_____________.
A. Right dose
B. Right time
C. Right person
D. All of the above
50) Preclinical study denotes which of the following:
A. Experiments on humans
B. Experiments on animals
C. Experiments using softwares
D. Experiments using simulations
51) Drug interactions can be managed by__________________.
A. Avoiding the physician
B. Avoiding the combinations
C. Avoiding the drugs at all
D. All of the above
52) Steven-Johnsons syndrome is_______________.
A. Liver necrolysis
B. Skin disorder
C. Tubules problem of drug induced kidney diseases
D. Myocardial tissue necrosis
53) Therapeutic drug monitoring is applicable to______________.
A. High therapeutic index
B. Drugs are in clinical trial
C. Narrow therapeutic Index
D. All options are correct
54) Select the common
secondary effect (side effect) of antipsychotic, antiparkinson and
antidepressant drugs.
A. Antiadrenergic
effect
B. Anticholinergic effect
C. Antihypertensive effect
D. Antidiuretic effect
55) Which phase of the clinical trial is referred as pharmacovigilance?
A. Phase-I
B. Phase-II
C. Phase-III
D. Phase-IV
56) The interaction between penicillin and probenecid belongs to which
type of drug interaction.
A. Over The Counter (OTC) drug interaction
B. Drug food interaction
C. Drug laboratory test Interaction
D. Prescription drug interaction
57) Which of the following statement is suitable for the term placebo
in clinical trials?
A. Substances that are similar to drugs + do not contain any
pharmacologically active drug
B. Substances that are different to drugs + contain pharmacologically
active drug
C. Substances that are similar to drugs + contain pharmacologically
active drug
D. Substances that are different to drugs + do not contain any
pharmacologically active drug
58) The goal of TDM is to ensure the________________.
A. Maximum therapeutic benefits
B. Minimum therapeutic benefits
C. Maximum toxic effects
D. None of the above
59) A medication error is________________.
A. A preventable event cause or lead to inappropriate medication use
B. Medical Emergency
C. Pharmacist is responsible for the event
D. None of these
60) With respect to the drug development process the NDA means__________________.
A. New Document Application
B. National Drug Application
C. New Drug Application
D. Novel Drug Application
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1. A |
2. A |
3. A |
4. D |
5. A |
6. B |
7. A |
8. D |
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9. B |
10. A |
11. B |
12. C |
13. C |
14. D |
15. A |
16. B |
|
17. C |
18. C |
19. A |
20. C |
21. D |
22. C |
23. A |
24. C |
|
25. D |
26. C |
27. D |
28. C |
29. B |
30. B |
31. B |
32. D |
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33. B |
34. A |
35. A |
36. C |
37. B |
38. B |
39. B |
40. C |
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41. A |
42. B |
43. D |
44. A |
45. A |
46. B |
47. B |
48. A |
|
49. D |
50. B |
51. B |
52. B |
53. C |
54. B |
55. D |
56. D |
|
57. A |
58. A |
59. A |
60. C |
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 PHARMACOLOGY-IV (Clinical Pharmacy and drug interaction) T 4.8.5){kind=link}
1 Comments
Very good effort mcqs help students to understand and memorize the aspect for a long time.
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